Conjugation: HRP: Horseradish Peroxidase
Description of Target: ITPK1 is the kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. It may also act as an isomerase that interconverts the inositol tetraphosphate isomers Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP and magnesium. It probably acts as the rate-limiting enzyme of the InsP6 pathway. ITPK1 modifies TNF-alpha-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain.
Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human ITPK1
Key Reference: Chamberlain,P.P., (2007) J. Biol. Chem. 282 (38), 28117-28125
Molecular Weight: 45kDa
Peptide Sequence: Synthetic peptide located within the following region:
MEVVQLNLSRPIEEQGPLDVIIHKLTDVILEADQNDSQSLELVHRFQEYIProduct Format: Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.
Protein Name: Inositol-tetrakisphosphate 1-kinase
Protein Size: 414
Purification: Affinity Purified
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