J27644

Formulation: A solid

Formal Name: 4-((8-chloro-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl)methyl)-N-hydroxybenzamide

Purity: ≥95%

Formula Markup: C16H12ClN3O4

Formula Weight: 345,7

Shelf life (days): 1095

Notes: J27644 is an inhibitor of histone deacetylase 6 (HDAC6; IC50 = 10 nM).{72123} It is selective for HDAC6 over HDAC1-5 (IC50s = 211-516 nM) and HDAC7, -8, -9, and -11 (IC50s = 137-812 nM). J27644 (10 µM) reduces the level of proteins involved in fibrosis, including collagen 1A1, α-smooth muscle actin (α-SMA), and fibronectin, in human pulmonary fibroblasts in vitro.

• SKU: CAY39469-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 39469-1
• Green Labware: No
• Package Unit: 1 mg
• Quantity Unit: STK