Product Type: Inhibitor
CAS No.: 99533-80-9
MolecularFormula: C27H21N3O5
Molecular Weight: 467,5
Source: Nonomuraea longicatena
Purity: ≥98% (HPLC)
Solubility: Soluble to 25 mM in DMSO
Appearance: White solid
PubChem CID: 11612445
Scientific Background: K252A is a non-selective protein kinase inhibitor that exhibits a wide range of effects. Specifically, it has been seen to inhibit PKA, PKC, PKG, CAM kinase II, mlCK, Ser/Thr kinase, Met, and receptor tyrosine kinases. It has been shown to prevent autophosphorylation and activation of downstream effectors.
References: 1. Morotti A., Mila S., Accorner, P., Tagliabue E., & Ponzetto C. (2002) Oncogene. 21(32): 4885–4893. 2. Hashimoto Y., et al. (1991) Biochem. Biophys. Res. Comm. 181(1): 423–429.3. Raychaudhuri S.P., Sanyal M., Weltman H., & Kundu-Raychaudhuri S. (2004) J. Invest. Derm. 122(3): 812–819.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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