Product Type: Inhibitor
CAS No.: 99570-78-2
MolecularFormula: C26H19N3O5
Molecular Weight: 453,5
Source: Synthetic
Purity: ≥98% (HPLC)
Solubility: Soluble in DMSO (1 mg/ml) or dimethyl formamide (1 mg/ml)
Appearance: White solid
PubChem CID: 9981344
Scientific Background: K252B is a non-selective, protein kinase inhibitor. It inhibits CaMKII, MYLK, PKA, PKC, and cGKI. It acts by binding to the ATP binding domain of the kinase. K252B is cell permeable.
References: 1. Nakanishi S., Matsuda Y., Iwahashi K., & Kase H. (1986) J. Antibiotics 39(8): 1066–1071.2. Teshima R., et al. (1997) J. Immun. 159(2): 964–969.3. Knüsel B., et al. (1992) J. Neurochem. 59(2): 715–722.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.