Target: KCNQ1
Conjugate: ATTO 594
Product Type: Monoclonal
Clone Number: N37A/10 (Formerly sold as S37A-10)
Immunogen: Fusion protein amino acids 2-101 of human KCNQ1
Swiss-Prot: P51787
Purification: Protein G Purified
Storage Buffer: PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Concentration: 1 mg/ml
Specificity: Detects ~75kDa.
Cellular Localization: Cell Membrane,Cytoplasmic Vesicle Membrane
Scientific Background: Kv7.1 (KvLQT1) is a potassium channel protein coded for by the gene KCNQ1. Kv7.1 is present in the cell membranes of cardiac muscle tissue and in inner ear neurons (1) among other tissues. In the cardiac cells, Kv7.1 mediates the IKs (or slow delayed rectifying K+) current that contributes to the repolarization of the cell, terminating the cardiac action potential and thereby the heart's contraction (2, 3).
References: 1. Lang F., Vallon V., Knipper M., Wagenmann P. (2007) Am J Physiol. 293(4): C1187-1208.2. Kurokawa J., et al. (2009) Channels (Austin). 3(1): 16-24.3. Silva J., and Rudy Y. (2005) Circulation. 112(10): 1384-1391.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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