Target: KCNQ4
Conjugate: Unconjugated
Product Type: Monoclonal
Clone Number: N43/6 (Formerly sold as S43-6)
Immunogen: Fusion protein amino acids 2-77 of human KCNQ4
Swiss-Prot: P56696
Purification: Protein G Purified
Storage Buffer: PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Concentration: 1 mg/ml
Specificity: Detects ~77kDa.
Cellular Localization: Plasma Membrane,Basal Cell Membrane
Scientific Background: The protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability (1), particularly in sensory cells of the cochlea (2). The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug (3).
References: 1. Hernandez C.C., Zaiko O., Tolstykh G.P., Shapiro M.S. (2008) J Physiol. 586(7): 1811-1821.2. Kharkovets T., et al. (2006) EMBO J. 25(3): 642-652.3. Tatulian L., Delmas P., Abogadie F.C., Brown D.A. (2001) J Neuroscience. 21(15): 5535-5545.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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