Product Type: Antagonist
CAS No.: 83846-83-7
MolecularFormula: C22H22FN3O3 • C4H6O6
Molecular Weight: 545,5
Source: Synthetic
Purity: >98% (HPLC); NMR (Conforms)
Solubility: May be dissolved in DMSO (30 mg/ml); or Water (5 mg/ml)
Appearance: White powder
PubChem CID: 135348
Scientific Background: A selective serotonin 5-HT2A receptor antagonist (IC50 = 6.3 nM) (1). Also exhibits significant selectivity for the human 5-HT1Dα receptor (2). Was shown to be effective for the treatment of hypertension following coronary artery surgery (3). It has been used to disrupt the hallucinogenic effects of psilocybin and to explore cognitive effects of the 5-HT2A receptor (4).
References: 1. Leysen JE., et al. (1981) Life Sci. 28:1015.2. Zgombick JM., et al. (1995) Eur. J. Pharmacol. 291:9.3. Vandenbroucke G., et al.(1994) J. Cardiothorac. Vasc. Anesth. 8: P324.4. Quednow BB.,et al. (2012) Neuropsychopharmacology. 37:630.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
English
Deutsch
