Product Type: Inhibitor
CAS No.: 126643-37-6
MolecularFormula: C29H25N3O5
Molecular Weight: 495,5
Source: Synthetic
Purity: ≥98% (TLC)
Solubility: Soluble in DMSO (20 mg/ml), dimethyl formamide (20 mg/ml) and ethyl acetate (5 mg/ml)
Appearance: White solid
PubChem CID: 3843
Scientific Background: KT5823 is a potent, selective, and reversible inhibitor of Protein Kinase G (PKG). It is a derivative of K-252a. KT5823 has been shown to inhibit SNP-stimulated PKG activity in dispersed smooth muscle cells. It has also been observed to dose-dependently inhibit spontaneous apoptosis of neutrophils.
References: 1. Murthy K.S., & Makhlouf G.M. (1995) Am J. Phys. 268(1 Pt 1): C171–180.2. Brunetti M., et al. (2002) Biochem. Biophys. Res. Comm. 297(3): 498–501.3. Kase H., et al. (1987) Biochem. Biophys. Res. Comm. 142(2): 436–440.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
English
Deutsch
