Formulation: A solid
Formal Name: 2S-amino-butanoic acid
Purity: ≥98%
Formula Markup: C4H9NO2
Formula Weight: 103,1
Shelf life (days): 1460
CAS Number: 1492-24-6
Notes: L-2-Aminobutyric acid is a non-proteinogenic amino acid.{65836} It inhibits LPS-induced nitric oxide (NO) production in, and reduces the bactericidal activity of, isolated mouse bone marrow-derived macrophages (BMDMs) when used at concentrations of 0.1 and 1 mM. L-2-Aminobutyric acid (75 mg/kg) increases survival in mouse models of sepsis induced by LPS or cecum ligation and puncture and decreases disease severity in a mouse model of inflammatory bowel disease (IBD) induced by dextran sodium sulfate (DSS; Item No. 23250). Serum levels of L-2-aminobutyric acid are increased in patients with COVID-19 and increased serum levels are associated with higher overall survival in patients with head and neck cancer.{65837,65838} It has been used in the synthesis of several compounds, including the antiepileptic levetiracetam (Item No. 9001820) and antimycobacterial agent ethambutol (Item No. 23713).{65839}
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