Formulation: A solid
Formal Name: L-phenylalanine-1,2,3,4,5,6-13C6
Purity: ≥99% deuterated forms (d1-d6)
Formula Markup: C3[13C]6H11NO2
Formula Weight: 171,2
Shelf life (days): 1460
CAS Number: 180268-82-0
Notes: L-Phenylalanine-13C6 is intended for use as an internal standard for the quantification of phenylalanine by GC- or LC-MS. L-Phenylalanine is an essential amino acid.{54554,54556,54555} Blood and brain levels of L-phenylalanine are increased and associated with progressive cognitive impairments, seizures, motor deficits, and autism in patients with phenylketonuria, an inborn error of metabolism characterized by mutations in the gene encoding phenylalanine hydroxylase (PAH). L-Phenylalanine inhibits NMDA-induced currents in primary rat hippocampal neurons (IC50 = 1.71 mM).{54554} It also assembles into fibrils in vitro that are cytotoxic to PC12 and CHO cells when used at concentrations ranging from 1.16 to 15 mM.{54556}
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