LAP (trifluoroacetate salt)

Formulation: A solid

Formal Name: (3S,9S,12S,15S,18S,21S,24S,27S,30R,33S,36S,39S,42S)-27-((1H-imidazol-4-yl)methyl)-3-(((S)-1-amino-1-oxo-3-phenylpropan-2-yl)carbamoyl)-24-(3-amino-3-oxopropyl)-36-(4-aminobutyl)-42-((S)-2-((S)-2-((S)-2-aminopropanamido)propanamido)-4-methylpentanamido)-9-benzyl-21,33-di((S)-sec-butyl)-18-(2-carboxyethyl)-12,15-bis(4-hydroxybenzyl)-30-(mercaptomethyl)-39-methyl-5,8,11,14,17,20,23,26,29,32,35,38,41-tridecaoxo-4,7,10,13,16,19,22,25,28,31,34,37,40-tridecaazapentatetracontanedioic acid, trifluoroacetate salt

Purity: ≥98%

Formula Markup: C99H141N23O27S • XCF3COOH

Formula Weight: 2117,4

Shelf life (days): 1460

Notes: Lupus autoantigen peptide (LAP) is an antiviral peptide derived from La, an autoantigen found in patients with systemic lupus erythematosus (SLE), that corresponds to amino acids 11-28 of La.{69511} It inhibits the interaction between the hepatitis C virus (HCV) 5’-UTR and internal ribosome entry site (IRES) trans-acting factors (ITAFs), including polypyrimidine tract-binding protein (PTB) and poly(rC)-binding protein 2 (PCBP2).{69512} LAP (60 µM) inhibits HCV IRES-mediated translation in a reporter assay using Huh7 cells, an effect that can be reversed by recombinant PTB and PCBP2.{69511,69512}

• SKU: CAY36982-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 36982-10
• Green Labware: No
• Package Unit: 10 mg
• Quantity Unit: STK