Product Type: Inhibitor
CAS No.: 231277-92-2
MolecularFormula: C29H26ClFN4O4S
Molecular Weight: 581,1
Source: Synthetic
Purity: ≥99%
Solubility: Solubility in water is 0.007 mg/ml and in 0.1N HCl is 0.001 mg/ml at 25° C
Appearance: Yellow crystalline solid
PubChem CID: 208908
Scientific Background: Lapatinib is a tyrosine kinase inhibitor. Specifically, it interrupts the ErbB/neu and epidermal growth factor receptor (EGFR) pathways. It is an antineoplastic agent used in breast cancer research. In solid tumor cells, Lapatinib binds to the ATP-binding pocket of the protein kinase domains on EGFR/ErbB, preventing self-phosphorylation.
References: 1. Chien A.J., et al. (2014) J. Clin. Oncol: J. Am. Clin. Oncol. 32(14): 1472–1479. 2. Dahal B.K., et al. (2010) Am. J. Resp. Critical Care Med. 181(2): 158–167.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.