Formulation: A solution in ethanol
Formal Name: (11β,16α)-9-fluoro-11,17-dihydroxy-16-methyl-21-[4-[(9Z,12Z)-9,12-octadecadien-1-yloxy]-1,4-dioxobutoxy]-pregna-1,4-diene-3,20-dione
Purity: ≥98%
Formula Markup: C44H65FO8
Formula Weight: 741
Shelf life (days): 365
CAS Number: 2102449-40-9
Notes: LD003 is a lipid prodrug form of the synthetic glucocorticoid dexamethasone (Item No. 11015) that has been used in the formation of lipid nanoparticles (LNPs) for siRNA and mRNA delivery in vivo.{68925} LNPs containing LD003 and encapsulating cytosine-guanine-containing oligodeoxynucleotide (CpG) reduce the blood levels of Il-10, chemokine (C-X-C motif) ligand 1 (CXCL1), TNF-α, IL-1β, and IL-6 in mice. LNPs containing LD003 and encapsulating siRNA targeting mouse coagulation Factor VII (FVII) decrease injection site immune infiltration and hepatic levels of FVII in mice.
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