LDN193189 , CAS 1062368-24-4

Product Description: LDN193189 is a highly potent small molecule inhibitor of bone morphogenetic protein (BMP) type I receptors ALK2 and ALK3. BMPs induce Smad1/5/8 plus non-Smad pathways, such as MAPK and Akt. BMP signaling pathway is the key regulator of cell fate decisions during embryogenesis and tissue homeostasis. It inhibits the activation of p38, ERK1/2 and Akt in C2C12 cells. LDN193189 only weakly inhibits ALK4, ALK5, and ALK7. LDN193189 affects not only the Smad but also the non-Smad signalling pathways induced by either BMP2, BMP6 or GDF5.

CAS Number: 1062368-24-4

Molecular Weight: 406.48

Structure: C25H22N6

Compound Purity: >98%

• SKU: CGSSM23-5
• Manufacturer: Cell Guidance Systems
• Manufacturer SKU: SM23-5
• Package Unit: 5 mg
• Quantity Unit: STK