Product Type: Inhibitor
CAS No.: 75706-12-6
MolecularFormula: C12H9F3N2O2
Molecular Weight: 270,21
Source: Synthetic
Purity: >98% (TLC: 5:95, CH3OH/CH2Cl2; Rf=0.65); NMR (Conforms)
Solubility: May be dissolved in DMSO (30 mg/ml); or Ethanol (27 mg/ml)
Appearance: White crystalline solid
PubChem CID: 3899
Scientific Background: Leflunomide is an Immuno-suppressant, it inhibits de novo synthesis of pyrimidine nucleotides and the activity of the protein kinase. It is a part of the known “disease-modifying anti-rheumatic drugs” (DMARD). It has been suggested that leflunomide modulates the expansion of activated autoimmune lymphocytes acting on the regression of rheumatoid conditions (1-2). It has been shown to have a double mechanism of action by slowing down and relieving the pain of rheumatoid arthritis. Studies have shown the lethal effects of Leflunomide after administration to mice in various doses (3).
References: 1. Fukushima R., Kanamori S., Hirashiba M., et al. (2007) Reprod. Toxical. 24(3-4): 310-316.2. Smolen JS., Emery P. (2000) Rheumatology. 39: 48-56.3. Fox R.I., Herrman M.L., Franqou C.G., Wahl G.M., Morns R.E., Strand V. and Kirschbaum B.S. (1999) Clin Immunol 93(3): 198-208.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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