Product Type: Inducer
CAS No.: 191732-72-6
MolecularFormula: C13H13N3O3
Molecular Weight: 259,26
Source: Synthetic
Purity: >98% (TLC); NMR (Conforms)
Solubility: Soluble in DMSO (200 mM), Water (<1 mM) and Ethanol (<1 mM).
Appearance: Powder
PubChem CID: 216326
Scientific Background: Clinically, lenalidomide has proven to be effective in the treatment of multiple myeloma and other B cell diseases. It has the ability to selectively bind and ubiquitinate two lymphoid transcription factors, IKZF1 and IKZF2, via the CRBN-CRL4 ubiquitin ligase. This ultimately leads to the degradation of IKZF1 and IKZF2, which are both essential in myeloma cell survival.
References: 1. Krönke J., et al. (2014) Science. 343(6168): 301-5.2. Lu G., et al. (2014) Science. 343(6168): 305-9.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
English
Deutsch
