Product Description: Leupeptin hemisulfate is a broad-spectrum, membrane-permeable protease inhibitor. Leupeptin hemisulfate potently inhibits serine, cysteine and threonine proteases. Leupeptin hemisulfate inhibits Mpro (the main protease of SARS-CoV-2) and also has anti-inflammatory activity[1][2][3].
Applications: COVID-19-immunoregulation
Formula: C20H38N6O4.1/2H2SO4
Citations: Antiviral Res. 2020 Oct;182:104922./Autophagy. 2021 Aug;17(8):1873-1888./Autophagy. 2021 Jul;17(7):1592-1613./Autophagy. 2024 Aug 30./Autophagy. 2024 Jun 19./Biochem Pharmacol. 2022: 115339./bioRxiv. 2020 Jun./bioRxiv. 2023 Nov 5./bioRxiv. 2024 November 14./Br J Pharmacol. 2023 Feb 14./Cancer Lett. 2022 Mar 9;215629./Cell Death Differ. 2022 Aug 22./Cell Death Dis. 2022 Oct 12;13(10):865./Cell Rep. 2021 Nov 2;37(5):109931./Environ Toxicol. 2023 Nov 23./Int J Oncol. 2019 Jul;55(1):331-339./J Biol Chem. 2021, 100616./J Clin Invest. 2022 Mar 1;132(5):e152170./J Hematol Oncol. 2024 Sep 2;17(1):78./mBio. 2024 Jun 28:e0053224./Mol Biomed. 2023 Nov 17;4(1):42./Natl Sci Rev. 2021 Feb 10;8(7):nwab024./Nature. 2024 Aug;632(8025):686-694./Nature. 2024 Aug;632(8026):930-937./Neuro Oncol. 2022 Jun 21;noac157./Oncol Rep. 2021 Dec;46(6):253./Pharmacol Res. 2024 Jun 28:107252./Sci Adv. 2021 Jan 1;7(1):eabe1340./Sci Rep. 2022 Jul 16;12(1):12197./Toxicol Appl Pharmacol. 2023 May 26;116568./Biochem Pharmacol. 2024 Dec 19:116720./Biochim Biophys Acta Mol Cell Res. 2023 Jan 24;1870(3):119433./Carbohydr Polym. 2023 Jun 9, 121108./Chem Asian J. 2024 Sep 2:e202400824./Emerg Microbes Infect. 2023 Apr 26;2207688./Int J Biol Macromol. 2023 Jul 3;125670./Nature. 2023 Jun;618(7966):799-807./Redox Biol. 2024 Apr:70:103064./Redox Biol. 2024 Mar 8, 103100.
References: [1]Fu L, et al. Mechanism of Microbial Metabolite Leupeptin in the Treatment of COVID-19 by Traditional Chinese Medicine Herbs. mBio. 2021 Oct 26;12(5):e0222021./[2]Haspel J, et al. Characterization of macroautophagic flux in vivo using a leupeptin-based assay. Autophagy. 2011 Jun;7(6):629-42./[3]Aoyagi T, et al. Biological activities of leupeptins. J Antibiot (Tokyo). 1969 Nov;22(11):558-68./[4]Aoyagi T, et al. Biological activities of leupeptins. J Antibiot (Tokyo). 1969 Nov;22(11):558-68.
CAS Number: 103476-89-7
Molecular Weight: 475.59
Compound Purity: 99.39
Research Area: Infection; Inflammation/Immunology
Solubility: H2O : 70 mg/mL (ultrasonic)
Target: Cathepsin;Ser/Thr Protease;Virus Protease
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