Conjugation: FITC: Fluorescein Isothiocyanate
Description of Target: LIF is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface.Leukaemia inhibitory factor is a cytokine that induces macrophage differentiation. Neurotransmitters and neuropeptides, well known for their role in the communication between neurons, are also capable of activating monocytes and macrophages and inducing chemotaxis in immune cells. LIF signals through different receptors and transcription factors. LIF in conjunction with BMP2 acts in synergy on primary fetal neural progenitor cells to induce astrocytes. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human LIF
Key Reference: Robertson,M.W., (2008) Cancer Invest. 26 (3), 222-229
Molecular Weight: 22kDa
Peptide Sequence: Synthetic peptide located within the following region:
KVLAAGVVPLLLVLHWKHGAGSPLPITPVNATCAIRHPCHNNLMNQIRSQProduct Format: Liquid. Purified antibody supplied in 1x PBS buffer.
Protein Name: Leukemia inhibitory factor
Protein Size: 202
Purification: Affinity Purified
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