Formulation: A solution in methyl acetate
Formal Name: ((2-((4-(dimethylamino)butanoyl)oxy)ethyl)azanediyl)bis(octane-8,1-diyl) bis(2-hexyldecanoate)
Purity: ≥95%
Formula Markup: C56H110N2O6
Formula Weight: 907,5
Shelf life (days): 730
CAS Number: 2430034-05-0
Notes: Lipid 14 is an ionizable cationic amino lipid that has been used in the formation of lipid nanoparticles (LNPs).{67335} LNPs containing lipid 14 and encapsulating mRNA encoding severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike glycoprotein receptor-binding domain (RBD), also known as the surface glycoprotein RBD, increase anti-RBD antibody levels in mice, as well as increase the number of isolated mouse splenocytes secreting IFN-γ and IL-2, but not IL-4 or IL-10, when incubated with the SARS-CoV-2 spike glycoprotein. LNPs containing lipid 14 and encapsulating mRNA encoding the bacterial Caf1 (F1) capsule antigen from Y. pestis, the bacteria that causes bubonic plague, induces anti-F1 cellular and humoral responses and protects against lethal Y. pestis infection in mice.{67277}
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