Lipid HTO12

Formulation: A solution in ethanol

Formal Name: heptadecan-9-yl 8-((2-hydroxyethyl)(2-hydroxytetradecyl)amino)octanoate

Purity: ≥98%

Formula Markup: C41H83NO4

Formula Weight: 654,1

Shelf life (days): 1460

Notes: Lipid HTO12 is an ionizable cationic lipid (pKa = 6.432) that has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo.{67778} LNPs containing lipid HTO12 and encapsulating adenine base editor mRNA targeting Pcsk9 reduce hepatic Pcsk9 levels in mice at a reduced ionizable lipid/total lipids-to-mRNA ratio than LNPs containing SM-102 (Item No. 33474).

• SKU: CAY41202-25
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 41202-25
• Package Unit: 25 mg
• Quantity Unit: STK