Formulation: A solution in ethanol
Formal Name: 2-butyl-octanoic acid, 1,1′-[[(3-hydroxypropyl)imino]di-9,1-nonanediyl] ester
Purity: ≥98%
Formula Markup: C45H89NO5
Formula Weight: 724,2
Shelf life (days): 1095
CAS Number: 2096984-25-5
Notes: Lipid III-45 is an ionizable cationic lipid (pKa = 6.25).{67404} It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo.{67404,67405,67406} LNPs containing lipid III-45 and encapsulating a luciferase mRNA reporter accumulate in liver and adipose tissue in mice.{67404,67405} LNPs containing lipid III-45 have been used to deliver an mRNA sequence encoding an antibody targeting the tumor-associated antigen and tight junction integral protein claudin-18 isoform 2 (claudin-18.2) to mice and reduce tumor volume in an MDA-MB-231 mouse xenograft model.{67406}
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