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Clone Name: ARC63830
Application Note: WB: 1:500-1:1000. IHC-P: 1:50-1:200. FACS: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 522
Form: Liquid
Buffer (with preservative): PBS, 0.05% BSA, 50% glycerol, 0.05% proclin300.
Concentration: Batch dependent (Please refer to the vial label for the specific concentration.)
Background: The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).[provided by RefSeq, Aug 2009]
Uniprot ID: P98164
Antigen Species: Human
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 4446-4655 of human intracellular Megalin/LRP2 (NP_004516.2).
Purification: Purified by affinity chromatography
Conjugation: Unconjugated
Full Name: LDL receptor related protein 2
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