Target: LRRK2
Conjugate: FITC
Product Type: Monoclonal
Clone Number: N231B/34 (Formerly sold as S231B-34)
Immunogen: Fusion protein amino acids 841-960 of human LRRK2. 81% identical in mouse, 80% identical in rat. <30% identity with LRRK1.
Swiss-Prot: Q5S007
Purification: Protein G Purified
Storage Buffer: PBS pH 7.4, 50% glycerol, 0.1% sodium azide *Storage buffer may change when conjugated
Concentration: 1 mg/ml
Specificity: Detects >200kDa.
Cellular Localization: Cytoplasm,Membrane,Mitochondrion,Golgi Apparatus,Cell Projection,Axon,Dendrite,Endoplasmic Reticulum,Cytoplasmic Vesicle,Endosome,Lysosome
Scientific Background: LRRK2 is a large protein with multiple domains including several ankyrin, leucine-rich, and WD40 repeats, a Ras-like small GTPase family domain named Roc, and a kinase domain that is closely related to the RIP kinase domain. LRRK2 gene is expressed in brain as well as in other tissues such as lung, liver and heart. LRRK2 might be central to the pathogenesis of several major neurodegenerative diseases associated with parkinsonism. Several dominantly inherited missense mutations in the gene encoding LRRK2 have been identified in several families that exhibit a broad spectrum of neuropathological features.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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