Clone Name: 2-4A5-4
Light Chain: Kappa
Calculated MW: 108
Form: Liquid
Buffer (with preservative): 0.2μm-filtered PBS pH7.0, no preservative.
Concentration: 4-11 mg/ml (Please refer to the vial label for the specific concentration.)
Background: The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Alternative splicing results in multiple transcript variants. Expression of a splice variant from an LTR promoter has been found in Hodgkin lymphoma (HL), HL cell lines and anaplastic large cell lymphoma. [provided by RefSeq, Mar 2017]
Uniprot ID: P07333
Antigen Species: Human
Immunogen: Rat NRK cells expressing transduced human M-CSF Receptor.
Purification: Protein G purified
Conjugation: Unconjugated
Full Name: colony stimulating factor 1 receptor
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