Formulation: A solid
Formal Name: 6aR,12aR-dihydro-6H-[1,3]dioxolo[5,6]benzofuro[3,2-c][1]benzopyran-3-ol
Purity: ≥95%
Formula Markup: C16H12O5
Formula Weight: 284,3
Shelf life (days): 1460
CAS Number: 2035-15-6
Notes: Maackiain is a cyclized isoflavonoid that has been found in S. flavescens and has anti-inflammatory and antiallergenic activities.{51685,51686,51684} It inhibits increases in the levels of mRNA encoding the histamine H1 receptor induced by phorbol 12-myristate 13-acetate (PMA; Item No. 10008014) in serum-starved HeLa cells when used at concentrations of 10, 20, or 30 µM and inhibits PMA-induced increases in the levels of mRNA encoding Il-4 in RBL-2H3 cells at 50 or 150 µM.{51685} Maackiain decreases LPS-induced increases in nitric oxide (NO) production in RAW 264.7 macrophages (IC50 = 27 µM).{51686} It increases survival in a mouse model of sepsis induced by cecal ligation and puncture (CLP) when administered at doses of 2.5 or 5 mg/kg.{51684} Maackiain (20 mg/kg per day) reduces the number of sneezes and the extent of nasal redness, swelling, and watery rhinorrhea in a rat model of allergies induced by toluene-2,4-diisocyanate (TDI).{51685}
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