Kategorie: Cytokines
Formulation: lyophilized
Storage: -20°C
Weight: 7.9 kD
Purity: >97%
Description: Rat recombinant CL22 produced in E.coli is a non-glycosylated, polypeptide chain containing 68 amino acids and having a molecular mass of 7.9kDa. MDC (CCL22) is a small cytokine that belongs to the CC chemokine family. CCL22 is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. MDC shows chemotactic activity for natural killer cells, chronically activated T lymphocytes, monocytes and dendritic cells. On the other hand, MDC shows a mild activity for primary activated T lymphocytes and has no chemoattractant activity for neutrophils, eosinophils and resting T lymphocytes. MDC may also have a role in the trafficking of activated T lymphocytes to inflammatory sites and other aspects of activated T lymphocyte physiology. MDC interacts with cell surface chemokine receptors CCR4.
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