Clone Name: 3C2
Light Chain: Kappa
Application Note: WB: 1:500-1:1000. ICC/IF: 1:100. IHC-P: 1:200. IP: 1:10-1:100. ELISA: 1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 80
Specificity/Sensitivity: We do not recommend use of this product for Mouse.,Knockdown/Knockout validation was supported by references (PMID: 26205822).
Form: Liquid
Buffer (with preservative): Tris-Glycine pH 7.5, 0.15M NaCl, 0.05% sodium azide.
Concentration: 1 mg/ml (Please refer to the vial label for the specific concentration.)
Background: This gene encodes an enzyme belonging to the glycosyl hydrolase 47 family. This enzyme functions in N-glycan biosynthesis, and is a class I alpha-1,2-mannosidase that specifically converts Man9GlcNAc to Man8GlcNAc isomer B. It is required for N-glycan trimming to Man5-6GlcNAc2 in the endoplasmic-reticulum-associated degradation pathway. Mutations in this gene cause autosomal-recessive intellectual disability. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 11. [provided by RefSeq, Dec 2011]
Uniprot ID: Q9UKM7
Antigen Species: Human
Immunogen: Full length human recombinant ERManI [Swiss-Prot# Q9UKM7].
Purification: Protein G purified
Conjugation: Unconjugated
Full Name: mannosidase alpha class 1B member 1
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