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Amino Acid Sequence: EAAGIGILTV
Applications: Stimulation of human MART-1 specific CD8+ T cells.
Background: MART-1 (Also known as Melan-A) is a differentiation antigen expressed at the surface of melanocytes. A peptide fragment of the protein is found bound to MHC complexes that are recognized by cytotoxic T cells. MART-1 is found in most skin cancers, including melanomas, and is used as a biomarker for diagnostic purposes. Since the expression of the protein is restricted to melanocytes containing tissues (skin and retina) and is not found in other tissues, MART-1 is an attractive target for cancer vaccines and adoptive cell therapy. MART-1 peptide 26-35 is a fragment commonly associated with MHC and recognized by T cell receptors.
Description: The Melanoma-associated antigen recognized by T cells-1 (MART-1) peptide (26-35, EAAGIGILTV) corresponds to MART-1 amino acids 26-35. This native peptide has higher binding affinity towards MART-1-specific T cells than the slightly smaller MART-1 peptide (27-35, AAGIGILTV, BPS Bioscience #78761), but has lower binding affinity and stability than the mutated MART-1 peptide (26-35, Leu27; ELAGIGILTV, BPS Bioscience #78760) analog.
Formulation: 1 mM peptide in DMSO
Storage Stability: At least one year at -80°C. Upon first thaw, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles.
Supplied As: Liquid, 100 µl
Warnings: Avoid freeze/thaw cycles
Biosafety Level: Not applicable (BSL-1)
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