Maytansine, CAS 35846-53-8

Formulation: A solid

Purity: ≥98%

Formula Markup: C34H46ClN3O10

Formula Weight: 692,2

Shelf life (days): 1460

CAS Number: 35846-53-8

Notes: Maytansine is an ansa macrolide originally isolated from M. serrata that has anticancer activity.{58875} It inhibits the growth of L1210, L-5178-Y, and P388 murine leukemia cells (EC50s = 0.6, 12, and 1.5 nM, respectively). Maytansine (20 µM) inhibits erythrocyte and brain tubulin polymerization.{58876} In vivo, maytansine (0.025-0.1 mg/kg) increases survival in a P388 murine leukemia model.{58875} It has also been used in the synthesis of cytotoxic payload moieties of antibody-drug conjugates (ADCs).{58877}

• SKU: CAY36062-500
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 36062-500
• Green Labware: No
• Package Unit: 500 µg
• Quantity Unit: STK
• Application: Reinstoffe