Formulation: 500 µl of peptide affinity-purified polyclonal antibody
Immunogen: Human MBOAT2, internal region (cytoplasmic)
Shelf life (days): 1095
Notes: Membrane-bound O-acyltransferase 2 (MBOAT2) is a membrane-spanning enzyme of the MBOAT family encoded by the LPCAT4 gene in humans.{27302} It contains multiple transmembrane domains and has two active site residues, an asparagine and a histidine, in common with other MBOAT family members.{27302} MBOAT2 is expressed in mouse epididymis, brain, testis, and ovary and is localized to the endoplasmic reticulum in CHO cells.{35639} MBOAT2 has acyltransferase activities, with a preference for using oleoyl-coenzyme A (oleoyl-CoA) as an acyl donor and lysophosphatidylethanolamine (Item No. 25844), lysophosphatidic acid, or lysophosphatidylcholine (Item No. 24331) as acyl acceptors at the sn-2 position.{27123} MBOAT2 expression is increased in the epithelia of patient-derived pancreatic ductal adenocarcinoma (PDAC) tumor tissue and this expression is inversely correlated with patient survival.{56207} In contrast, decreased expression of serum circular MBOAT2 RNA levels are found in patients with hypertrophic cardiomyopathy.{56208} Cayman’s MBOAT2 (Internal) Polyclonal Antibody can be used for flow cytometry and immunofluorescence applications. The antibody recognizes the internal (cytoplasmic) portion of MBOAT2.
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