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Encompassing Amino Acids: 2-304(end)
Applications: Useful as an immunogen or as a substrate for phosphorylation, citrullination, or methylation studies.
Background: MBP is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. MBP is also present in the bone marrow and the immune system. Differential splicing events combined with post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. MBP is commonly used as a substrate for many kinases and methyltransferases.
Description: Human myelin basic protein (MBP), GenBank Accession No. NM_001025101, a.a. 2-304(end), with N-terminal His-tag, MW=34 kDa, expressed in an E. coli cell expression system.
Format: Aqueous buffer solution
Formulation: 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 200 mM imidazole, 5 mM DTT, 0.04% Tween-20, 20% glycerol.
Genbank: NM_001025101
Storage Stability: Store at -80°C. Stable for >6 months when stored as directed.
Tags: N-terminal His-tag
Uniprot: P02686
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. Kishimoto, A., et al., J. Biol. Chem. 1985;260(23):12492-12499.
2. Quandt, J.A., et al., J. Immunol. 2012;189(6):2897-2908.
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