Formulation: A solid
Formal Name: 9-ethyl-3-(5-phenyl-1H-1,2,3-triazol-1-yl)-9H-carbazole
Purity: ≥98%
Formula Markup: C22H18N4
Formula Weight: 338,4
Shelf life (days): 1460
CAS Number: 2097938-73-1
Notes: MBQ-167 is a dual inhibitor of Rac and cell division cycle 42 (Cdc42; IC50s = 103 and 78 nM, respectively).{68283} It reduces Rac and Cdc42 GTP binding and GTPase activity and limits migration and mammosphere formation in MDA-MB-231 breast cancer cells when used at a concentration of 250 nM. MBQ-167 (250 nM), alone and in combination with the kinase inhibitor lapatinib (Item No. 11493), reduces cell viability and induces apoptosis in lapatinib-resistant SK-BR-3 and MDA-MB-435 breast cancer cells.{68284} It also reduces growth rates, axial budding, and Cdc42 activity in S. cerevisiae when used at a concentration of 200 µM.{68285} Intraperitoneal administration of MBQ-167 (1 or 10 mg/kg three times per week) reduces tumor growth in an MDA-MB-435 mouse xenograft model.{68283}
English
Deutsch
