Product Description: MC-GGFG-Exatecan (MC-GGFG-DX8951) is a agent-linker conjugate for ADC. MC-GGFG-Exatecan is a DX8951 (a DNA topoisomerase I inhibitor) derivative with protease cleavable MC-GGFG linker. MC-GGFG-Exatecan shows antitumor activity and can be used to prepare DX8951 antibody conjugate (ADC)[1].
Applications: Cancer-programmed cell death
Formula: C49H51FN8O11
References: [1]Nakada T, et al. Novel antibody drug conjugates containing exatecan derivative-based cytotoxic payloads. Bioorg Med Chem Lett. 2016 Mar 15;26(6):1542-1545.
CAS Number: 1600418-29-8
Molecular Weight: 946.97
Compound Purity: 99.71
Research Area: Cancer
Solubility: DMSO : 50 mg/mL (ultrasonic)
Target: Drug-Linker Conjugates for ADC;Topoisomerase