MD2-TLR4-I, CAS 2249801-12-3

Formulation: A solid

Formal Name: 2,6-dichloro-N-[3-(1H-indol-5-yl)-1H-indazol-5-yl]-benzamide

Purity: ≥98%

Formula Markup: C22H14Cl2N4O

Formula Weight: 421,3

Shelf life (days): 1460

CAS Number: 2249801-12-3

Notes: MD2-TLR4-I is a toll-like receptor 4 (TLR4) antagonist.{68392} It inhibits LPS-induced production of TNF-α and IL-6 in primary mouse macrophages (IC50s = 0.89 and 0.53 µM, respectively). MD2-TLR4-I inhibits LPS-induced, TLR4-mediated NF-κB activation in a reporter assay using RAW 264.7 cells. In vivo, MD2-TLR4-I (10 mg/kg) reduces lung macrophage infiltration and prevents lung edema and alveolar thickening in a mouse model of LPS-induced acute lung injury.

• SKU: CAY38328-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 38328-10
• Package Unit: 10 mg
• Quantity Unit: STK
• Application: Reinstoffe