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Clone Name: MSVA-617R
Product Description: This antibody was validated on 76 different Normal Tissues by IHC-P.
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Application Note: IHC-P: 1:100-1:200. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 70
Positive Control: Skin: A moderate to strong cytoplasmic PMEL immunostaining should be seen in all melanocytes of the skin.
Negative Control: Colon: PMEL immunostaining should be completely absent in all cells.
Form: Liquid
Buffer (with preservative): 10mM PBS, 0.05% BSA (Please contact us for sodium azide-free or sodium azide and BSA-free format), 0.05% sodium azide.
Concentration: 0.2 mg/ml (Please refer to the vial label for the specific concentration.)
Background: This gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2011]
Uniprot ID: P40967
Antigen Species: Human
Immunogen: Recombinant fragment of human SILV protein
Purification: Protein A/G purified
Conjugation: Unconjugated
Full Name: premelanosome protein
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