Formulation: Lyophilized from sterile 20 mM Tris, 500 mM sodium chloride, 10% glycerol, pH 8.0
Purity: ≥90% as estimated by SDS-PAGE
Formula Weight: 0
Shelf life (days): 365
Notes: Middle East respiratory syndrome coronavirus (MERS-CoV) spike glycoprotein is a viral structural protein that contains the receptor-binding domain (RBD).{62983} MERS-CoV is an enveloped positive-stranded RNA virus, a member of the Betacoronavirus genus, and the causative agent of MERS, an acute respiratory disease that often leads to pneumonia and renal failure.{62983,62985} The MERS-CoV spike glycoprotein mediates viral attachment to host cells and virus-cell-mediated membrane fusion during infection.{62983} It is composed of an S1 subunit, which contains the RBD that binds to host dipeptidyl peptidase-4 (DPP-4), and an S2 subunit containing heptad repeat regions 1 and 2, which are responsible for membrane fusion, as well as a transmembrane domain and a cytoplasmic tail. The RBD of the MERS-CoV spike glycoprotein is one of the targets for neutralizing antibodies.{62983} Cayman's MERS-CoV Spike Glycoprotein RBD (Strain EMC/2012) (recombinant) protein consists of 251 amino acids and has a calculated molecular weight of 27.7 kDa.
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