Methyltetrazine-DBCO, CAS 1802238-48-7

Product Description: Methyltetrazine-DBCO is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Methyltetrazine-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. Methyltetrazine-DBCO also contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

Applications: Cancer-programmed cell death

Formula: C34H33N7O7S

References: [1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

CAS Number: 1802238-48-7

Molecular Weight: 683.73

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: ADC Linker

• SKU: MEXHY-140313-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-140313-0
• Green Labware: No
• Package Unit: Get quote
• Quantity Unit: STK