Abbreviation: Mfsd2a
Target Synonym: NLS1;Mfsd2;1700018O18Rik;Mfsd2a
Conjugation: Unconjugated
UNIProt ID: Q9DA75
Background: Sodium-dependent lysophosphatidylcholine (LPC symporter, which plays an essential role for blood-brain barrier formation and function. Specifically expressed in endothelium of the blood-brain barrier of micro-vessels and transports LPC into the brain. Transport of LPC is essential because it constitutes the major mechanism by which docosahexaenoic acid (DHA, an omega-3 fatty acid that is essential for normal brain growth and cognitive function, enters the brain. Transports LPC carrying long-chain fatty acids such LPC oleate and LPC palmitate with a minimum acyl chain length of 14 carbons. Does not transport docosahexaenoic acid in unesterified fatty acid. Specifically required for blood-brain barrier formation and function, probably by mediating lipid transport. Not required for central nervous system vascular morphogenesis. Acts as a transporter for tunicamycin, an inhibitor of asparagine-linked glycosylation.
Concentration: 1mg/mL
Immunogen: Recombinant fusion protein of mouse Mfsd2a
Dilution: WB 1:500-1:2000
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