MG-132, CAS 133407-82-6

Proteasome Inhibitor

Product Type: Inhibitor

CAS No.: 133407-82-6

MolecularFormula: C26H41N3O5

Molecular Weight: 475,6

Source: Synthetic

Purity: >98%

Solubility: Soluble in 45 mg/ml DMSO, DMF and ethanol

Appearance: White solid

PubChem CID: 462382

Scientific Background: Specific inhibitor of the 20S proteasome (Ki=4 nM). Blocks NFKB activation by blocking IKB proteolysis (IC50=3 M). It stimulates autophagy, induces heat shock response and is cell permeable

References: 1. Tsubuki S., et al. (1996) J. Biochem. 119:572.2. Wu W.K., et al. (2010) Autophagy 6:228.3. Meriin A.B., et al. (1998) J. Biol. Chem. 273:6373.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• SKU: STRSIH-326-5MG
• Manufacturer: Stressmarq Biosciences
• Manufacturer SKU: SIH-326-5MG
• Package Unit: 5 mg
• Quantity Unit: STK