Formulation: A solid
Formal Name: 2-(2,4,6-trichlorophenyl)hydrazone, 1-(5-chloro-2-hydroxyphenyl)-ethanone
Purity: ≥95%
Formula Markup: C14H10Cl4N2O
Formula Weight: 364,1
Shelf life (days): 1460
CAS Number: 219315-22-7
Notes: Mitochondrial fusion promoter M1 is a promoter of mitochondrial fusion.{69654} It induces elongation of mitochondria in mitofusin-1 knockout (Mfn1-/-) or Mfn2-/- mouse embryonic fibroblasts (MEFs; EC50s = 5.3 and 4.42 µM, respectively) and protects against MPP+-induced mitochondrial fragmentation and cytotoxicity in SH-SY5Y cells when used at a concentration of 5 µM. M1 (1 µM) reduces apoptosis and inhibits decreases in testosterone levels induced by the organophosphate triphenyl phosphate in TM3 mouse Leydig cells.{69655} In vivo, mitochondrial fusion promoter M1 (2 mg/kg) improves novel object recognition deficits induced by the antitumor antibiotic doxorubicin (Item No. 15007) in rats.{69656}
English
Deutsch
