Formulation: A solid
Formal Name: α-[2-(2,4-difluorophenyl)-2-oxoethyl]-1H-indole-3-acetic acid
Purity: ≥98%
Formula Markup: C18H13F2NO3
Formula Weight: 329,3
Shelf life (days): 1460
CAS Number: 1354707-41-7
Notes: Mitochonic acid 5 is an inhibitor of mitochondrial dysfunction.{65222} It increases intracellular ATP levels in Hep3B cells when used at a concentration of 3 µM. Mitochonic acid 5 (5 µM) rescues LPS-induced apoptosis and decreases in the mitochondrial membrane potential in BV-2 microglial cells.{65223} It protects against decreases in cell viability induced by L-buthionine-(S,R)-sulfoximine (BSO; Item No. 14484) in fibroblasts isolated from patients with various mitochondrial diseases, including Leigh syndrome and Leber’s hereditary optic neuropathy (EC50s = 2.3-5.1 µM), in an electron transport chain-independent manner.{65222} Mitochonic acid 5 (50 mg/kg) reduces plasma levels of creatinine and decreases acute renal tubular necrosis in a mouse model of bilateral retroperitoneal renal ischemia-reperfusion injury.{65224}
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