Formulation: A crystalline solid
Formal Name: 2-[4-(3S)-3-piperidinylphenyl]-2H-indazole-7-carboxamide, 4-methylbenzenesulfonate
Purity: ≥98%
Formula Markup: C19H20N4O • C7H8O3S
Formula Weight: 492,6
Shelf life (days): 1460
CAS Number: 1038915-73-9
Notes: MK-4827 is an orally bioavailable inhibitor of poly(ADP-ribose) polymerase 1 (PARP1) and PARP2 (IC50s = 3.8 and 2.1 nM, respectively).{34138} It inhibits the proliferation of cancer cells carrying the breast cancer mutations BRCA1 and BRCA2 in vitro (IC50 values range from 10-100 nM) and has efficacy alone against a xenograft of BRCA1-deficient cancer in mice.{34138,20554} MK-4827 sensitizes human lung and breast cancer xenografts to radiation in mice.{34140} Formulations containing MK-4827 are effective against ovarian cancer, particularly in platinum-sensitive, recurrent ovarian cancer.{34139}
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