ML-198, CAS 1380716-06-2

Formulation: A solid

Formal Name: N-(4-ethynylphenyl)-5,7-dimethyl-pyrazolo[1,5-a]pyrimidine-3-carboxamide

Purity: ≥98%

Formula Markup: C17H14N4O

Formula Weight: 290,3

Shelf life (days): 1460

CAS Number: 1380716-06-2

Notes: ML-198 is a chemical chaperone of glucocerebrosidase.{51286} It activates hydrolysis of the fluorescent glucocerebrosidase substrate 4-methylumbelliferyl-β-D-glucopyranoside (4-MUG; Item No. 20948) in spleen homogenate isolated from patients with Gaucher disease with the homozygous N370S mutant of glucocerebrosidase (glucocerebrosidaseN370S; AC50 = 0.36 µM). ML-198 (5 µM) increases the translocation of glucocerebrosidaseN370S to lysosomes in dermal fibroblasts isolated from patients with Gaucher disease.

• SKU: CAY37755-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 37755-1
• Package Unit: 1 mg
• Quantity Unit: STK
• Application: Reinstoffe