Application Note: WB: 1:1000. IHC-P: 1:400. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 54
Form: Liquid
Buffer (with preservative): PBS, 0.09% sodium azide.
Concentration: Batch dependent (Please refer to the vial label for the specific concentration.)
Background: This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to lack protein kinase activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (Rip3), which is a key signaling molecule in necroptosis pathway. Knockout of this gene in mice showed that it is essential for necroptosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2015]
Uniprot ID: Q9D2Y4
Antigen Species: Mouse
Immunogen: KLH conjugated synthetic peptide between 444-472 amino acids from the C-terminal region of mouse Mlkl.
Purification: Protein A purified followed by antigen-affinity chromatography
Conjugation: Unconjugated
Full Name: mixed lineage kinase domain-like
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