mlN4924, CAS 905579-51-3

NEDD8 activating enzyme inhibitor

Product Type: Inhibitor

CAS No.: 905579-51-3

MolecularFormula: C21H25N5O4S

Molecular Weight: 443,2

Source: Synthetic

Purity: >98%

Solubility: Soluble in 10 mg/ml DMSO

Appearance: White Powder

PubChem CID: 16720766

Scientific Background: Potent and selective NEDD8-activating enzyme (NAE) inhibitor. It disrupts cullin-RING ligase-mediated protein turnover leading to apoptosis in human tumor cells. It suppresses the growth of human tumor xenografts in mice. Cell permeable.

References: 1. Soucy T.A., et al. (2009) Nature. 458:732.2. Milhollen M.A., et al. (2010) Blood. 116:1515.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• SKU: STRSIH-331-1MG
• Manufacturer: Stressmarq Biosciences
• Manufacturer SKU: SIH-331-1MG
• Package Unit: 1 mg
• Quantity Unit: STK