Scientific Background: Potent and selective NEDD8-activating enzyme (NAE) inhibitor. It disrupts cullin-RING ligase-mediated protein turnover leading to apoptosis in human tumor cells. It suppresses the growth of human tumor xenografts in mice. Cell permeable.
References: 1. Soucy T.A., et al. (2009) Nature. 458:732.2. Milhollen M.A., et al. (2010) Blood. 116:1515.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.