Products from BPS Bioscience require a minimum order value above 400€
Applications: Great for studying enzyme kinetics and HTS applications.
Background: MMP11 (matrix metalloproteinase 11), also known as Stromelysin-3 (SL-3), is a member of the matrix metalloproteinase (MMP) family involved in the degradation of the extracellular matrix. MMP11 was initially discovered in breast carcinoma and has since been identified in diverse carcinomas and developmental processes. MMP-11 promotes cancer development by inhibiting apoptosis as well as enhancing migration and invasion of cancer cells. MMP11 is activated by furin, an enzyme linked to the entry of the SARS-CoV-2 virus into cells.
Description: The Fluorogenic MMP11 Assay Kit is designed to measure MMP11 activity for screening and profiling applications, in a homogeneous assay with no time-consuming washing steps.
Storage Stability: At least one year from date of receipt when stored as directed.
Supplied As: The kit comes in a convenient 96-well format, with purified MMP11 enzyme, fluorogenic substrate, and MMP assay buffer for 100 enzyme reactions.
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. Peruzzi, Daniela, et al. 2009. "MMP11: a novel target antigen for cancer immunotherapy." Clinical Cancer Research 15(12): 4104-4113.
2. Cheng, Chun-Wen, et al. 2010. "The clinical implications of MMP-11 and CK-20 expression in human breast cancer." Clinica Chimica Acta 411(3-4): 234-241.
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