Products from BPS Bioscience require a minimum order value above 400€
Applications: Great for studying enzyme kinetics and HTS applications.
Background: MMP12 (matrix metalloproteinase 12) is a member of the matrix metalloproteinase (MMP) family involved in the degradation of the extracellular matrix. MMP12 is also associated with the regulation of cytokines and chemokines, suggesting a role for MMP12 in inflammation. MMP12 is also essential for arterial stiffening in mice and is a highly prognostic marker of arterial stiffness, making MMP12 a therapeutic target for cardiovascular disease.
Description: The Fluorogenic MMP12 Assay Kit is designed to measure MMP12 activity for screening and profiling applications, in a homogeneous assay with no time-consuming washing steps.
Storage Stability: At least one year from date of receipt when stored as directed.
Supplied As: The kit comes in a convenient 96-well format, with purified MMP12 enzyme, fluorogenic substrate, and MMP assay buffer for 100 enzyme reactions.
Biosafety Level: Not applicable (BSL-1)
References: 1. Morris, D.G., et al. 2003. "Loss of integrin αvβ6-mediated TGF-β activation causes MMP12-dependent emphysema." Nature 422(6928): 169-173.
2. Hunninghake, G.M., et al. 2009. "MMP12, lung function, and COPD in high-risk populations." New England Journal of Medicine 361(27): 2599-2608.
English
Deutsch
