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Applications: Great for studying enzyme kinetics and HTS applications.
Background: MMP13 (matrix metalloproteinase 13), also known as collagenase 3, is a member of the matrix metalloproteinase (MMP) family involved in the degradation of the extracellular matrix. MMP13 primarily cleaves type II collagen, and it is expressed in the skeleton where it plays a role in restructuring the collagen matrix for bone mineralization and cartilage turnover. MMP13 is also overexpressed in rheumatoid arthritis, osteoarthritis, and many human carcinomas, suggesting its potential as a therapeutic target.
Description: The Fluorogenic MMP13 Assay Kit is designed to measure MMP13 activity for screening and profiling applications, in a homogeneous assay with no time-consuming washing steps.
Storage Stability: At least one year from date of receipt when stored as directed.
Supplied As: The kit comes in a convenient 96-well format, with purified MMP13 enzyme, fluorogenic substrate, and MMP assay buffer for 100 enzyme reactions.
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. Wang, M., et al. MMP13 is a critical target gene during the progression of osteoarthritis. Arthritis Res Ther 15: R5 (2013).
2. Li, H., et al. New insights on the MMP-13 regulatory network in the pathogenesis of early osteoarthritis. Arthritis Res Ther 19: 248 (2017).
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