Products from BPS Bioscience require a minimum order value above 400€
Applications: Great for studying enzyme kinetics and HTS applications.
Background: MMP14 (matrix metalloproteinase 14) is a member of the matrix metalloproteinase (MMP) family involved in the degradation of the extracellular matrix.MMP14 regulates the activity of multiple extracellular and plasma membrane proteins, influencing cell-cell and cell-extracellular matrix (ECM) degradation and remodeling, cell invasion, and cancer metastasis. MMP14 is highly expressed in most sarcomas, and levels of MMP14 correlate with breast cancer progression. Upregulation of MMP14 also promotes glioma invasion and tumor cell proliferation and plays a role in angiogenesis.
Description: The Fluorogenic MMP14 Assay Kit is designed to measure MMP14 activity for screening and profiling applications, in a homogeneous assay with no time-consuming washing steps.
Storage Stability: At least one year from date of receipt when stored as directed.
Supplied As: The kit comes in a convenient 96-well format, with purified MMP14 enzyme, fluorogenic substrate, and MMP assay buffer for 100 enzyme reactions.
Biosafety Level: Not applicable (BSL-1)
References: 1. Chun, Tae-Hwa, et al. 2010. "Genetic link between obesity and MMP14-dependent adipogenic collagen turnover." Diabetes 59(10): 2484-2494.
2. Chen, Tzy-Yen, et al. 2011. "Role of MMP14 gene polymorphisms in susceptibility and pathological development to hepatocellular carcinoma." Annals of Surgical Oncology 18(8): 2348-2356.
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